Kawasaki T, Kambayashi J, Uemura Y, Sakon M, Shiba E, Suehisa E, Amino N, Mori T
Department of Surgery II, Osaka University Medical School, Japan.
Int Angiol. 1995 Mar;14(1):65-8.
Although various hematological disorders have been considered to be etiologic factors in deep vein thrombosis (DVT), the involvement of dysplasminogenemia (DPG) in DVT has not been studied in detail. In 72 consecutive DVT patients, the presence of DVT was suspected based on a history of lower limb swelling and tenderness with acute onset, and was confirmed by duplex scanning, radioisotope venography, or contrast venography. DPG was identified by the observation of dissociation between the activity and antigenicity of plasminogen. Of the 72 patients, 9 (12.5%) were diagnosed as having DPG, and several antithrombin-III deficiency and protein C and S deficiency were identified. The mean age of the genetically normal and DPG patients was 52 +/- 15 and 40 +/- 15 years, respectively (p < 0.05). Thus, these findings suggest that DPG is deeply related to the development of DVT, and that abnormality of the fibrinolytic system is one of the major etiologic factors in DVT.
尽管各种血液系统疾病被认为是深静脉血栓形成（DVT）的病因，但异常纤溶酶原血症（DPG）在DVT中的作用尚未得到详细研究。在72例连续性DVT患者中，根据急性起病的下肢肿胀和压痛病史怀疑存在DVT，并通过双功扫描、放射性核素静脉造影或造影剂静脉造影得以证实。通过观察纤溶酶原活性与抗原性之间的解离来确定DPG。在这72例患者中，9例（12.5%）被诊断为患有DPG，同时还发现了几例抗凝血酶III缺乏症以及蛋白C和S缺乏症。基因正常患者和DPG患者的平均年龄分别为52±15岁和40±15岁（p<0.05）。因此，这些发现表明DPG与DVT的发生密切相关，并且纤溶系统异常是DVT的主要病因之一。
