钙离子载体A23187引发人血小板中磷脂酶A2的活性。
Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187.
作者信息
Pickett W C, Jesse R L, Cohen P
出版信息
Biochim Biophys Acta. 1976 Jan 18;486(1):209-13. doi: 10.1016/0005-2760(77)90086-8.
PMID:827311
Abstract
Phospholipase A2 activity in a suspension of intact platelets was induced by addition of a Ca2+-ionophore, A23187. This action of ionophore A23187 was enhanced by EGTA and inhibited by an excess of Ca2+ in the medium, findings which suggest that A23187 is able to mobilize intracellular Ca2+ for the latter's role as an essential cofactor for phospholipase A2 activity.
摘要
通过添加钙离子载体A23187诱导完整血小板悬液中的磷脂酶A2活性。EGTA增强了离子载体A23187的这一作用，而培养基中过量的Ca2+则抑制了该作用，这些发现表明A23187能够动员细胞内的Ca2+，使其作为磷脂酶A2活性的必需辅助因子发挥作用。
Zotero 插件