Jensen J S, Borch-Johnsen K, Feldt-Rasmussen B F, Jensen G
Steno Diabetes Center, Gentofte.
Ugeskr Laeger. 1993 Dec 20;155(51):4155-7.
Microalbuminuria, defined as a urinary albumin excretion rate of 20-200 micrograms/min, predicts diabetic nephropathy and cardiovascular disease in diabetic patients. An increased urinary albumin excretion rate is probably also associated with cardiovascular disease in non-diabetic subjects. Thus, screening for microalbuminuria is of major importance. A semi-quantitative urinary dipstick method, Micral-Test, has been developed for this purpose. In a urine sample collected overnight from each of 1359 subjects the Micral-Test was evaluated with a quantitative ELISA-method as the standard. Sensitivity, specificity and diagnostic specificity in detecting microalbuminuria was 92, 58 and 12% respectively. The prevalence of microalbuminuria was 5.6%. In conclusion, the Micral-Test is highly sensitive in detecting microalbuminuria, but at the expense of a relatively high number of false positive tests.
微量白蛋白尿定义为尿白蛋白排泄率20 - 200微克/分钟，可预测糖尿病患者的糖尿病肾病和心血管疾病。尿白蛋白排泄率升高可能也与非糖尿病受试者的心血管疾病有关。因此，筛查微量白蛋白尿至关重要。为此已开发出一种半定量尿试纸法，即Micral-Test。在从1359名受试者中每人收集的过夜尿液样本中，以定量ELISA法作为标准对Micral-Test进行评估。检测微量白蛋白尿的敏感性、特异性和诊断特异性分别为92%、58%和12%。微量白蛋白尿的患病率为5.6%。总之，Micral-Test在检测微量白蛋白尿方面高度敏感，但代价是假阳性检测数量相对较高。
