Clapp N, Henke M, Hansard R, Carson R, Fretland D
Marmoset Research Center, Oak Ridge (MARCOR), Oak Ridge Assoc. Univ., TN.
Agents Actions. 1993;39 Spec No:C36-8. doi: 10.1007/BF01972713.
To evaluate anti-colitic efficacy, eight cotton-top tamarins (CTTs) with histologically confirmed persistent active colitis were given the anti-inflammatory agent SC-41930 (10 mg/kg BW by gavage BID) for eight weeks. Colonic endoscopy and biopsy observations, CBCs and clinical chemistries, and stool consistency were evaluated pre-, mid-, and posttreatment. Colitic activity was graded histologically from A1 (mild) to A5 (severe); results varied among the seven animals that completed the study: five improved, one worsened, and one was unchanged. Serum enzyme levels were significantly reduced with treatment. Stool condition remained puddly throughout treatment and body weights did not vary from pretreatment levels. However, SC-41930 produced histological evidence (reduced numbers of polymorphonuclear cells) of anti-colitic efficacy over an eight-week treatment period in CTTs with persistent active colitis. These results support the use of the CTT colitis model to evaluate efficacy of therapeutic agents and provide useful predictive information to aid in the medical management of human IBD.
为评估抗结肠炎疗效，对八只经组织学确诊患有持续性活动性结肠炎的棉顶狨猴（CTT）给予抗炎药SC - 41930（按体重10 mg/kg，经口灌胃，每日两次），持续八周。在治疗前、治疗中期和治疗后，对结肠进行内镜检查和活检观察、进行全血细胞计数和临床化学检测，并评估粪便稠度。根据组织学将结肠炎活动程度从A1（轻度）分级至A5（重度）；在完成研究的七只动物中，结果各异：五只病情改善，一只恶化，一只无变化。治疗后血清酶水平显著降低。在整个治疗过程中，粪便状况一直呈稀软状，体重与治疗前水平无差异。然而，在为期八周的治疗期内，SC - 41930在患有持续性活动性结肠炎的CTT中产生了抗结肠炎疗效的组织学证据（多形核细胞数量减少）。这些结果支持使用CTT结肠炎模型来评估治疗药物的疗效，并为人类炎症性肠病的医学管理提供有用的预测信息。
