A comparative trial of hyposensitization in 1973 in the treatment of hay fever using Pollinex and Alavac-P.

A direct comparison was made in 112 hay fever patients of hyposensitization treatment with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex) and with alum-precipitated pyridine extract (Alavac-P) which is an accepted form of treatment, its efficacy having been shown by a comparative trial against a placebo preparation. No significant difference could be detected between the results of the two forms of treatment. Seventy-seven per cent of patients responded with improvement following treatment with the tyrosine adsorbed vaccine, and 81% of those receiving the alum-precipitated vaccine. Side effects from treatment, both local and general, were generally of an infrequent or mild nature for both vaccines.