Carrié D, Béard T, Sié P, Boudjemaa B, Delay M, Bernadet P
Clinique cardiologique, hôpital Purpan, Toulouse.
Arch Mal Coeur Vaiss. 1993 Jun;86(6):921-4.
The authors report a case of myocardial infarction in a 27 year old patient by simultaneous thrombosis of the left anterior descending and right coronary arteries in an angiographically normal coronary circulation. The young age of the patient, the absence of the usual risk factors and a normal angiographic network after arterial recanalisation by angioplasty led to the search for a risk factor of thrombosis. This showed a qualitative deficiency of protein S and the absence of any other abnormality of coagulation or fibrinolysis. This case raises the question of a causal relationship between a hereditary protein S deficiency and thrombotic arterial occlusion.
作者报告了一例27岁患者发生心肌梗死的病例,该患者在冠状动脉造影显示正常的情况下,左前降支和右冠状动脉同时发生血栓形成。患者年轻,不存在常见的危险因素,且血管成形术使动脉再通后血管造影显示血管网络正常,这促使人们寻找血栓形成的危险因素。结果发现蛋白S存在定性缺陷,且凝血或纤溶方面无任何其他异常。该病例引发了关于遗传性蛋白S缺乏与血栓性动脉闭塞之间因果关系的问题。