Van Look P F
Clin Obstet Gynaecol. 1976 Dec;3(3):555-78.
Failure of the hypothalamic-pituitary unit to release LH in response to oestrogen may be encountered with or without associated disturbance of negative feedback. Such positive feedback failures can be detected with the aid of an oestrogen provocation test. Application of this test in women presenting with anovulatory cycles permits one to distinguish between an hypothalamic or ovarian cause (e.g. deficient follicular development) for anovulation. In women with infrequent or absent menstruation and infertility an oestrogen provocation test, combined with basal gonadotrophin and prolactin measurement and pituitary response to LH-RH, may prove to be useful in selecting the appropriate treatment for induction of ovulation.
下丘脑 - 垂体单位对雌激素无反应而未能释放促黄体生成素（LH）的情况，可能伴有或不伴有负反馈的相关紊乱。这种正反馈失败可借助雌激素激发试验检测出来。将该试验应用于无排卵周期的女性，有助于区分无排卵的下丘脑性或卵巢性病因（如卵泡发育不全）。对于月经稀少或闭经且不孕的女性，雌激素激发试验结合基础促性腺激素和催乳素测定以及垂体对促黄体生成素释放激素（LH - RH）的反应，可能有助于选择合适的诱导排卵治疗方法。
