甲状腺激素对糖尿病大鼠肾细胞色素P450的调节作用

Regulation of renal cytochrome P450s by thyroid hormone in diabetic rats.

作者信息

Imaoka S, Nakamura M, Ishizaki T, Shimojo N, Ohishi N, Fujii S, Funae Y

机构信息

Laboratory of Chemistry, Osaka City University Medical School, Japan.

出版信息

Biochem Pharmacol. 1993 Dec 14;46(12):2197-200. doi: 10.1016/0006-2952(93)90609-z.

DOI:10.1016/0006-2952(93)90609-z

PMID:8274152

Abstract

Effects of thyroid hormone treatment on renal P450 expression in the diabetic rats were investigated. Diabetes produced by streptozotocin induced CYP4A2 and P450 K-2 (similar form with CYP2C23) but not P450 K-4 (similar form with CYP4A8) and induced lauric acid hydroxylation activity. The serum thyroid hormone level was decreased with diabetes. Treatment of diabetic rats with thyroid hormone (T3) as well as with insulin reversed the increase in the levels of CYP4A2 and P450 K-2. Thyroidectomy also induced CYP4A2 and P450 K-2 in the rat kidney. The increase was reversed by treatment of thyroidectomized rats with T3. These findings suggest that expression of CYP4A2 and P450 K-2 in rat kidney is suppressively regulated by thyroid hormone and the decrease in thyroid hormone level in the diabetic state affects the levels of CYP4A2 and P450 K-2.

摘要

研究了甲状腺激素治疗对糖尿病大鼠肾脏细胞色素P450表达的影响。链脲佐菌素诱导产生的糖尿病可诱导CYP4A2和P450 K-2（与CYP2C23类似的形式），但不诱导P450 K-4（与CYP4A8类似的形式），并诱导月桂酸羟化活性。糖尿病状态下血清甲状腺激素水平降低。用甲状腺激素（T3）以及胰岛素治疗糖尿病大鼠可逆转CYP4A2和P450 K-2水平的升高。甲状腺切除术也可诱导大鼠肾脏中的CYP4A2和P450 K-2。用T3治疗甲状腺切除的大鼠可逆转这种升高。这些发现表明，大鼠肾脏中CYP4A2和P450 K-2的表达受甲状腺激素的抑制调节，糖尿病状态下甲状腺激素水平的降低影响CYP4A2和P450 K-2的水平。