Shimojo N
Department of Laboratory Medicine, Osaka City University Medical School, Japan.
Int J Biochem. 1994 Oct-Nov;26(10-11):1261-8. doi: 10.1016/0020-711x(94)90095-7.
It is known that the metabolism of some drugs is altered in diabetic patients and in rats with experimental diabetes induced by chemical agents, such as streptozocin. The induction and/or suppression of hepatic cytochrome P450 isozymes seen in diabetes seem to contribute to this alteration. Both metabolic and hormonal disturbances following insulin deficiency in diabetic rats are responsible for these changes. Marked changes in hepatic P450 isozymes in diabetic rats include increases in the isozymes induced by ketones and lipids, including fatty acids, and decreases in the isozymes regulated by growth hormone and testosterone. Suppressed secretion of thyroid hormones also participates in the mechanism causing these changes. Analysis of cytochrome P450 isozymes in diabetic rats is helpful in elucidating the impaired metabolism of some endogenous substrates catalyzed by the cytochrome P450, such as steroid hormones and fatty acids, in diabetes. The results of these analyses also provide insight into the prescription of drugs for diabetic patients.
众所周知，糖尿病患者以及用链脲佐菌素等化学试剂诱导的实验性糖尿病大鼠体内，某些药物的代谢会发生改变。糖尿病中所见到的肝药酶细胞色素P450同工酶的诱导和/或抑制似乎促成了这种改变。糖尿病大鼠胰岛素缺乏后的代谢和激素紊乱都是这些变化的原因。糖尿病大鼠肝药酶细胞色素P450同工酶的显著变化包括由酮类和脂质（包括脂肪酸）诱导的同工酶增加，以及由生长激素和睾酮调节的同工酶减少。甲状腺激素分泌受抑制也参与了导致这些变化的机制。分析糖尿病大鼠的细胞色素P450同工酶有助于阐明糖尿病中细胞色素P450催化的一些内源性底物（如甾体激素和脂肪酸）代谢受损的情况。这些分析结果也为糖尿病患者的药物处方提供了参考。
