Pawlak D, Morelowska-Spierzak D, Azzadin A, Wróbel K, Buczko W
Department of Pharmacodynamics, Medical Academy, Bialystok, Poland.
Alcohol Alcohol. 1993 Sep;28(5):529-33.
The present study was designed to evaluate the kinetics of acetaldehyde (ACT) and and its action on the cardiovascular system in rats. ACT (3, 6, 12 mg/kg i.p.) causes accumulation of this metabolite in the blood, at a concentration corresponding to that obtained from ethanol metabolism after its administration in doses of 1, 2, 4 g/kg p.o., respectively. After intraperitoneal injection of ACT there were no significant changes in blood pressure and heart rate in comparison to the control group. It appears that, in rats, ACT has no influence on the function of the cardiovascular system after the ingestion of ethanol.
本研究旨在评估乙醛（ACT）的动力学及其对大鼠心血管系统的作用。腹腔注射ACT（3、6、12mg/kg）会导致该代谢产物在血液中蓄积，其浓度分别与口服1、2、4g/kg乙醇后乙醇代谢所获得的浓度相当。与对照组相比，腹腔注射ACT后血压和心率无显著变化。看来，在大鼠中，摄入乙醇后ACT对心血管系统功能没有影响。
