Pérez-Molina J J, Alfaro-Alfaro N, López-Zermeño M C, García-Calderón M A
Servicio de Neonatología, Nuevo Hospital Civil de Guadalajara, Jalisco, México.
Bol Med Hosp Infant Mex. 1993 Nov;50(11):803-8.
The purpose of the study is to determine the prevalence of polydactyly, its clinical characteristic and its association with some risk factors.
A retrospective, case-control study, of 45 newborn with polydactyly and their controls, in 26,670 consecutive births in the Nuevo Hospital Civil de Guadalajara, with 20 weeks or more of gestational age, and birth weight greater than 500 g, since November of 1988 to October of 1992. The information were obtained from the database of the Congenital External Malformation Register, carried out by the University of Guadalajara. The prevalence of polydactyly was obtained and clinical characteristic were documented. Continuous variables were compared using t Student test. For discrete variables, analysis were carried out using X2 test and the odds ratio.
The prevalence of polydactyly was of 1.73 x 1,000 alive newborn. The polydactyly of the hands in 26 newborn; preaxial in five and 21 was postaxial. The polydactyly in the foot was present in 19 newborn. The only statistics differences with control group were: low length and the antecedent of other malformation in the family.
The found prevalence is different to the one informed in the literature. The association with antecedent of another malformation in the family, support the role of hereditary factors in etiology.
本研究旨在确定多指(趾)畸形的患病率、临床特征及其与某些危险因素的关联。
一项回顾性病例对照研究,研究对象为瓜达拉哈拉新市民医院1988年11月至1992年10月期间连续出生的26670例孕周20周及以上、出生体重超过500g的新生儿,其中45例患有多指(趾)畸形的新生儿及其对照。信息来自瓜达拉哈拉大学建立的先天性外部畸形登记数据库。获取多指(趾)畸形的患病率并记录临床特征。连续变量采用t检验进行比较。对于离散变量,采用X²检验和比值比进行分析。
多指(趾)畸形的患病率为每1000例活产新生儿中有1.73例。26例新生儿手部多指(趾)畸形;其中5例为轴前型,21例为轴后型。19例新生儿足部多指(趾)畸形。与对照组的唯一统计学差异为:身长较短以及家族中有其他畸形病史。
本研究发现的患病率与文献报道的不同。与家族中其他畸形病史的关联支持了遗传因素在病因学中的作用。