Pérez-Molina J J, Alfaro-Alfaro N, Angulo-Castellanos E, Nario-Castellanos J G
División de Pediatría, Nuevo Hospital Civil de Gudalajara, México.
Bol Med Hosp Infant Mex. 1993 Feb;50(2):110-3.
The purpose of this article is to determine the prevalence of the cleft lip and palate and its association with some risking factors.
A retrospective, observational and analytic study, of 44 newborn infants with cleft lip and palate and their controls, in 33,461 consecutive births, with 20 weeks or more, and birth weight more than 500 g, since November of 1988 to June of 1991. The information were obtained from the database of the Congenital External Malformation Register, done by the University of Guadalajara, in four hospitals. The prevalence of the cleft lip and palate was calculated. Of the variables studied their association was searched with congenital malformation in 2 x 2 tables, calculating, its chi square, confidence interval, and old ratio.
The prevalence of the cleft lip and palate was of 13.2 x 10,000 births. By categories: cleft lip 2.7 x 10,000, cleft lip and palate 7.8 x 10,000 and cleft palate 2.7 x 10,000. The only statistics differences with control group were the association with antecedent of other malformation in the family and methrorrague during pregnancy.
The found prevalence is similar to the one informed in the literature, with some differences by categories. The association with antecedent of another malformation in the family, support the role of the hereditary role in the multifactorial etiology.
本文旨在确定唇腭裂的患病率及其与某些危险因素的关联。
一项回顾性、观察性和分析性研究，研究对象为1988年11月至1991年6月期间连续出生的33461例孕周20周及以上、出生体重超过500克的新生儿中44例唇腭裂患儿及其对照。信息来自瓜达拉哈拉大学在四家医院建立的先天性外部畸形登记数据库。计算唇腭裂的患病率。在2×2表格中研究变量与先天性畸形的关联，计算卡方、置信区间和比值比。
唇腭裂的患病率为每10000例出生中有13.2例。按类别划分：唇裂为每10000例中有2.7例，唇腭裂为每10000例中有7.8例，腭裂为每10000例中有2.7例。与对照组的唯一统计学差异是与家族中其他畸形病史以及孕期出血的关联。
所发现的患病率与文献报道的相似，但按类别存在一些差异。与家族中另一种畸形病史的关联支持了遗传因素在多因素病因学中的作用。
