Dohar J E, Goding G S, Maisel R H
Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh.
Arch Otolaryngol Head Neck Surg. 1994 Jan;120(1):74-7. doi: 10.1001/archotol.1994.01880250066009.
Using a dorsally based, random skin flap model in 14 swine, the influence on skin flap survival of isoflurane used with nitrous oxide as maintenance anesthetic agents was examined. The mean area of skin flap survival was 54.9% for the experimental group compared with 28.6% in the control group. Arterial blood gas content (PO2, PCO2, and HCO3-), respiratory rate, acid-base balance, blood pressure level, pulse rate, and temperature were monitored. Improved survival of the isoflurane-nitrous oxide group was independent of these parameters. These data support the findings of a previous study that isoflurane positively affects random skin flap survival in a swine model. Furthermore, the addition of nitrous oxide partially reduces isoflurane's beneficial effects.
在14头猪身上使用基于背部的随机皮瓣模型，研究了异氟烷与氧化亚氮作为维持麻醉剂对皮瓣存活的影响。实验组皮瓣存活的平均面积为54.9%，而对照组为28.6%。监测动脉血气含量（PO2、PCO2和HCO3-）、呼吸频率、酸碱平衡、血压水平、脉搏率和体温。异氟烷-氧化亚氮组皮瓣存活率的提高与这些参数无关。这些数据支持了先前一项研究的结果，即异氟烷对猪模型中的随机皮瓣存活有积极影响。此外，添加氧化亚氮会部分降低异氟烷的有益作用。
