Ivanov V V, Lusta I V, Sitozhevskiĭ A V, Trofimov A V, Kozhanova A A
Biull Eksp Biol Med. 1993 Aug;116(8):165-7.
The effect of pro-oxidants (tert-butyl peroxide and FeSO4) on rats perfusing isolated pancreas insulin secretion was studied. Pro-oxidants (10(-4) M) preperfusion during 20 minutes did not change significantly the basal insulin secretion and decreased glucose-stimulated secretion of the one. The content of pancreas TBA-active products increased twice after pro-oxidants effect and ratio of reduced and oxidized glutathiones liberation rates decreased from 2 to 0.5. The disturbance of hormone secretion as a result of decrease of Langerhans islets B-cells reduced glutathione pool is suppose to be one of the mechanisms of hypoinsulinemia development at host's states characterizing with lipids peroxidation activation.
研究了促氧化剂（叔丁基过氧化物和硫酸亚铁）对大鼠离体胰腺灌注胰岛素分泌的影响。促氧化剂（10⁻⁴ M）预灌注20分钟，对基础胰岛素分泌无显著影响，但可降低葡萄糖刺激的胰岛素分泌。促氧化剂作用后，胰腺中TBA活性产物的含量增加了两倍，还原型和氧化型谷胱甘肽释放率之比从2降至0.5。由于朗格汉斯胰岛B细胞还原型谷胱甘肽池减少导致激素分泌紊乱，被认为是脂质过氧化激活所表征的宿主状态下低胰岛素血症发生的机制之一。
