Zabrodskiĭ P F
Biull Eksp Biol Med. 1993 Aug;116(8):181-3.
The effects of acute poisoning with anticholinesterase insecticide dimethyldichlorvinylphosphate (DDVP) in doses 0.25; 0.5 and 1.0 LD 50, immobilisation stress (6-hour), hydrocortisone (100 mg/kg) and acetylcholine--A (5 mg/kg) on the basic immune responses were investigated in experiments on CBA mice. It was shown that increased migration of founder hemopoietic cells from the bone marrow was caused by the effect of A and that of T-cells from the thymus was induced by the actions of corticosterone (CS) and A. Suppressions of delayed-type hypersensitivity reaction, natural and antibody-dependent cellular cytotoxicity humoral immune response were directly associated with concentration of CS in the blood and inhibition of alpha-naphthylbutyratesterase in spleen cells. The function of nonspecific and specific mechanisms in the formation of immunodeficiency after intoxication with organophosphates chemicals was found to differ in immune resections under study.
在CBA小鼠实验中，研究了剂量为0.25、0.5和1.0半数致死量的抗胆碱酯酶杀虫剂二甲基二氯乙烯基磷酸酯（敌敌畏）急性中毒、固定应激（6小时）、氢化可的松（100毫克/千克）和乙酰胆碱-A（5毫克/千克）对基本免疫反应的影响。结果表明，A的作用导致骨髓中造血祖细胞迁移增加，而皮质酮（CS）和A的作用诱导胸腺中T细胞迁移。迟发型超敏反应、自然和抗体依赖性细胞毒性体液免疫反应的抑制与血液中CS浓度以及脾细胞中α-萘丁酸酯酶的抑制直接相关。发现有机磷化学品中毒后免疫缺陷形成中非特异性和特异性机制的功能在所研究的免疫反应中有所不同。
