嗜热四膜虫rDNA微型染色体的发育调控加工与复制
Developmentally regulated processing and replication of the Tetrahymena rDNA minichromosome.
作者信息
Kapler G M
机构信息
Department of Microbiology and Immunology, University of California, San Francisco 94143.
出版信息
Curr Opin Genet Dev. 1993 Oct;3(5):730-5. doi: 10.1016/s0959-437x(05)80091-7.
PMID:8274855
Abstract
The ribosomal DNA locus of Tetrahymena thermophila undergoes a dramatic series of developmentally regulated processing events to generate the amplified rDNA minichromosome during formation of the somatic macronucleus. DNA transformation and classical genetic approaches have identified cis-acting elements that regulate rDNA processing in the developing macronucleus and subsequent vegetative rDNA maintenance.
摘要
嗜热四膜虫的核糖体DNA位点经历了一系列由发育调控的显著加工事件，以便在体细胞大核形成过程中产生扩增的rDNA微型染色体。DNA转化和经典遗传学方法已经鉴定出顺式作用元件，这些元件在发育中的大核中调控rDNA加工以及随后的营养期rDNA维持。
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