Hiraga S
Department of Molecular Cell Biology, Kumamoto University School of Medicine, Japan.
Curr Opin Genet Dev. 1993 Oct;3(5):789-801. doi: 10.1016/s0959-437x(05)80100-5.
The past year has seen important genetic and biochemical advances in our understanding of the mechanisms that are involved in chromosome partition into two daughter cells in Escherichia coli. Topoisomerase IV and XerCD recombinase have been shown to be required for the unlinking of replicated chromosomes. MukB, an alpha-helical coiled-coil protein, has been shown to be involved in chromosome partition, and this is the first candidate for a bacterial motor protein. Another protein, FtsZ, has been shown to form a constriction ring in cell division and may also relate to chromosome partition.
在过去的一年里，我们对大肠杆菌中染色体分配到两个子细胞所涉及的机制的理解取得了重要的遗传学和生物化学进展。已证明拓扑异构酶IV和XerCD重组酶是复制染色体解链所必需的。MukB是一种α-螺旋卷曲螺旋蛋白，已证明其参与染色体分配，并且这是细菌运动蛋白的首个候选蛋白。另一种蛋白质FtsZ已证明在细胞分裂中形成收缩环，并且也可能与染色体分配有关。
