致病细菌中的一类稳定性决定因素。
A family of stability determinants in pathogenic bacteria.
作者信息
Hayes F
机构信息
Microbiology Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, England, UK.
出版信息
J Bacteriol. 1998 Dec;180(23):6415-8. doi: 10.1128/JB.180.23.6415-6418.1998.
Abstract
A novel segregational stability system was identified on plasmid R485, which originates from Morganella morganii. The system is composed of two overlapping genes, stbD and stbE, which potentially encode proteins of 83 and 93 amino acids, respectively. Homologs of the stbDE genes were identified on the enterotoxigenic plasmid P307 from Escherichia coli and on the chromosomes of Vibrio cholerae and Haemophilus influenzae biogroup aegyptius. The former two homologs also promote plasmid stability in E. coli. Furthermore, the stbDE genes share homology with components of the relBEF operon and with the dnaT gene of E. coli. The organization of the stbDE cassette is reminiscent of toxin-antitoxin stability cassettes.
摘要
在源自摩根氏摩根菌的质粒R485上鉴定出一种新型的分离稳定性系统。该系统由两个重叠基因stbD和stbE组成，它们可能分别编码83和93个氨基酸的蛋白质。在来自大肠杆菌的产肠毒素质粒P307以及霍乱弧菌和埃及嗜血杆菌生物群的染色体上鉴定出了stbDE基因的同源物。前两个同源物也促进了大肠杆菌中质粒的稳定性。此外，stbDE基因与relBEF操纵子的组分以及大肠杆菌的dnaT基因具有同源性。stbDE盒的组织让人联想到毒素-抗毒素稳定性盒。
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