Chambon P
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
Gene. 1993 Dec 15;135(1-2):223-8. doi: 10.1016/0378-1119(93)90069-f.
Retinoids are derivatives of vitamin A (retinol) that exert a wide variety of profound effects on vertebrate development, cellular differentiation and homeostasis. How these simple molecules can exert such pleiotropic effects has recently been an area of intensive investigation. A complex array of combinatorial effects is beginning to emerge from molecular and genetic studies, which may ultimately account for the pleiotropic effects of retinoids.
维甲酸是维生素A（视黄醇）的衍生物，对脊椎动物发育、细胞分化和体内平衡具有广泛而深刻的影响。这些简单分子如何发挥如此多效性作用，近来一直是深入研究的领域。分子和遗传学研究开始揭示出一系列复杂的组合效应，这最终可能解释维甲酸的多效性作用。
