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某些化学辐射防护剂对小鼠骨髓的影响。

Effect of some chemical radioprotectors on mouse bone marrow.

作者信息

Lata M, Ghose A, Khanna C M

机构信息

Radiation Biology Department, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.

出版信息

Indian J Exp Biol. 1993 Oct;31(10):843-6.

PMID:8276439
Abstract

Effect of HT, AET and Se on mice bone marrow has been studied by counting bone marrow micronucleated cells and endogenous spleen colony count (CFU-S). Combination of HT and AET used as a radioprotector has not caused any significant variation in any of the parameter studied when administered once, it increases bone marrow micronucleated cells and decreases CFU-S slightly after daily administration for 7 days. The individual constituent of the combination administered singly does not increase micronucleated cell number. Seven consecutive doses of HT + AET and same in combination with Se enhances micronucleated cells to a higher level. Daily injection of Se alone up to 7 days also causes an increase in micronucleated cells upto same level. CFU-S pool does not show any significant change in number of bone marrow cells through out the study except in the groups where animals were treated with Se.

摘要

通过计数骨髓微核细胞和内源性脾集落数(CFU-S),研究了羟基酪醇(HT)、氨基乙磺酸(AET)和硒对小鼠骨髓的影响。HT和AET联合用作辐射防护剂时,单次给药在所研究的任何参数中均未引起任何显著变化,但连续7天每日给药后,会增加骨髓微核细胞数量,并使CFU-S略有减少。单独给予组合中的单个成分不会增加微核细胞数量。连续七剂HT + AET以及与硒联合使用会将微核细胞提高到更高水平。连续7天每天单独注射硒也会使微核细胞数量增加到相同水平。在整个研究过程中,CFU-S池中的骨髓细胞数量没有显示出任何显著变化,但用硒处理动物的组除外。

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