Muthal A V, Chopde C T
Department of Pharmaceutical Sciences, Nagpur University Campus.
Indian J Physiol Pharmacol. 1993 Jul;37(3):238-40.
The influence of calcium channel blockers (CCB) on the analgesic activity of tricyclic antidepressants (TCA) was examined using hot plate (thermal) and writhing (chemical) method. Intraperitoneal injections of TCA, imipramine and amitriptyline or CCB viz: verapamil, nifedipine, nicardipine and cinnarizine per se produced analgesia. The Analgesic effect of TCA was further enhanced by prior treatment with CCB. The increase in TCA analgesia could not be ascribed to unitary mechanism but could possibly be mediated by opioid and/or nonopioid systems. These results clearly provide an evidence that a combination treatment of CCB and TCA may permit reduction of the TCA doses while treating chronic pain of organic origin.
使用热板（热刺激）和扭体（化学刺激）法研究了钙通道阻滞剂（CCB）对三环类抗抑郁药（TCA）镇痛活性的影响。腹腔注射TCA、丙咪嗪和阿米替林或CCB，即维拉帕米、硝苯地平、尼卡地平及桂利嗪本身均可产生镇痛作用。预先给予CCB可进一步增强TCA的镇痛效果。TCA镇痛作用的增强并非单一机制所致，可能是由阿片类和/或非阿片类系统介导的。这些结果清楚地证明，CCB与TCA联合治疗在治疗器质性慢性疼痛时可减少TCA的用量。
