Clinical efficacy of milbemycin oxime in the treatment of generalized demodicosis in adult dogs.

Thirty adult dogs with chronic generalized demodicosis were treated with oral administration of milbemycin oxime (0.52 to 3.8 mg/kg of body weight, q 24 h). Results of skin scrapings were used to determine whether administration of milbemycin should be continued or discontinued. Dogs that were free of clinical signs of demodicosis 12 months after administration of milbemycin was discontinued were considered cured. Sixteen dogs were cured, 5 dogs were never cleared of mites, and 9 dogs were cleared of mites, but relapsed after administration of milbemycin was discontinued. Adverse effects of milbemycin were rare and transient.