White S D, Rosychuk R A, Fieseler K V
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.
Vet Dermatol. 2001 Feb;12(1):13-8. doi: 10.1046/j.1365-3164.2001.00208.x.
Twenty-three dogs with positive skin scrapings for Cheyletiella sp. were treated with milbemycin oxime using a protocol approximating 2 mg kg-1 orally once weekly for three weeks. Nineteen of these dogs belonged to a household of 41 dogs and two dogs were in households with one other dog. All in-contact dogs were treated. Pre-treatment intradermal skin tests showed positive reactions to D. farinae in 13 dogs and to D. pteronyssinus in 12 dogs; these became negative post-treatment in four and seven dogs, respectively. All dogs showed a dramatic reduction in clinical signs one week after the third treatment. Eighteen dogs no longer had mites on skin scrapings, three had dead mites and two had deformed eggs. Recurrence of clinical signs necessitated two additional courses of the protocol in the multiple dog household and for a dog receiving immunosuppressive treatment for pemphigus foliaceus. Possible adverse reactions to the milbemycin (vomiting, lethargy) were noted once in two dogs.
23只皮肤刮片检查确诊为犬蠕形螨感染的犬，按照约2mg/kg口服，每周一次，共三周的方案，使用米尔贝肟进行治疗。其中19只犬来自一个有41只犬的家庭，另外两只犬来自有其他犬的家庭。所有接触过的犬都接受了治疗。治疗前皮内皮肤试验显示，13只犬对粉尘螨呈阳性反应，12只犬对屋尘螨呈阳性反应；治疗后，分别有4只和7只犬的反应转为阴性。第三次治疗一周后，所有犬的临床症状都显著减轻。18只犬的皮肤刮片检查不再发现螨虫，3只犬有死螨，2只犬有畸形卵。在多犬家庭中，有一只接受落叶型天疱疮免疫抑制治疗的犬，临床症状复发，需要再进行两个疗程的治疗。两只犬曾出现过一次米尔贝肟可能的不良反应（呕吐、嗜睡）。
