Jongen-Rĕlo A L, Groenewegen H J, Voorn P
Graduate School Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Faculty of Medicine, Department of Anatomy and Embryology, The Netherlands.
J Comp Neurol. 1993 Nov 8;337(2):267-76. doi: 10.1002/cne.903370207.
In the present study, the compartmental organization of the nucleus accumbens was investigated by comparing the pattern of leu-enkephalin immunoreactivity with that of the opioid receptor ligand, naloxone, an established marker for the compartmental organization of the neostriatum. Both patterns have a nonhomogeneous, patch-like appearance throughout the rostrocaudal extent of the nucleus and show a good, mutual correspondence. In the core of the nucleus accumbens as well as in the border region between the nucleus accumbens and the caudate-putamen, leu-enkephalin-rich areas are in register with opioid receptor-dense areas. In the shell region the precise relationship between the enkephalin and the naloxone patterns could not be established. A comparison of the connectivity patterns and neurochemical characteristics of the opioid receptor-dense compartments in the nucleus accumbens with those in the caudate-putamen reveals major discrepancies between these two striatal subdivisions. We therefore conclude that, rather than a bicompartmental patch/striosome-matrix organization, the nucleus accumbens has a multicompartmental organization.
在本研究中，通过比较亮氨酸脑啡肽免疫反应模式与阿片受体配体纳洛酮（一种已确立的新纹状体分区组织标记物）的模式，对伏隔核的分区组织进行了研究。这两种模式在伏隔核的整个前后范围内均呈现出不均匀的斑块状外观，且具有良好的相互对应关系。在伏隔核核心以及伏隔核与尾状核 - 壳核之间的边界区域，富含亮氨酸脑啡肽的区域与阿片受体密集区域相对应。在壳区，脑啡肽模式与纳洛酮模式之间的确切关系尚未确定。对伏隔核中阿片受体密集区与尾状核 - 壳核中阿片受体密集区的连接模式和神经化学特征进行比较，发现这两个纹状体亚区之间存在重大差异。因此，我们得出结论，伏隔核具有多分区组织，而非双分区的斑块/纹状体 - 基质组织。
