Department of Neuroscience and The Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA.
Cold Spring Harb Perspect Med. 2012 Oct 1;2(10):a011957. doi: 10.1101/cshperspect.a011957.
Psychostimulants robustly induce alterations in neuronal structural plasticity throughout brain reward circuits. However, despite our extensive understanding of how these circuits modulate motivated behavior, it is still unclear whether structural plasticity within these regions drives pathological behavioral responses in addiction. Although these structural changes have been subjected to an exhaustive phenomenological characterization, we still have a limited understanding of the molecular mechanisms regulating their induction and the functional relevance of such changes in mediating addiction-like behavior. Here we have highlighted the known molecular pathways and intracellular signaling cascades that regulate psychostimulant-induced changes in neuronal morphology and synaptic restructuring, and we discuss them in the larger context of addiction behavior.
精神兴奋剂强烈诱导整个大脑奖励回路中的神经元结构可塑性改变。然而，尽管我们对这些回路如何调节动机行为有了广泛的了解，但仍不清楚这些区域内的结构可塑性是否会导致成瘾中的病理性行为反应。尽管这些结构变化已经受到详尽的现象学描述，但我们对调节其诱导的分子机制以及这些变化在介导类似成瘾行为中的功能相关性的了解仍然有限。在这里，我们强调了已知的分子途径和细胞内信号级联，它们调节精神兴奋剂诱导的神经元形态和突触重构变化，并在更大的成瘾行为背景下讨论了它们。
