Canevari S, Furlan D, Mossa A, Figini M
Division of Experimental Oncology E, Istituto Nazionale Tumori, Milano, Italy.
Int J Biol Markers. 1993 Jul-Sep;8(3):147-50. doi: 10.1177/172460089300800302.
In only a few years, the technology of antibody engineering has demonstrated its power and a variety of recombinant monoclonal antibodies are now being developed. Recent developments in gene manipulation have allowed the isolation of antibodies, including human antibodies, with or without immunization, by displaying functional antibody fragments on the surface of bacteriophage particles and directly selecting with antigen. In the present review some recent achievements in these areas are highlighted.
在短短几年内，抗体工程技术已展现出其强大威力，目前正在研发多种重组单克隆抗体。基因操作方面的最新进展使得人们能够通过在噬菌体颗粒表面展示功能性抗体片段并直接用抗原进行筛选，来分离抗体，包括无需免疫的人源抗体。在本综述中，将重点介绍这些领域的一些最新成果。
