氰甲基苯并咪唑的反应。第三部分。氰甲基苯并咪唑与异氰酸酯和异硫氰酸酯的反应。
Reactions of cyanomethylbenzimidazoles. Part III. Reaction of cyanomethylbenzimidazoles with isocyanates and isothiocyanates.
作者信息
Milczarska B, Sawlewicz J, Manowska W
出版信息
Pol J Pharmacol Pharm. 1976;28(5):521-8.
PMID:827741
Abstract
In the reaction of 2-cyanomethylbenzmidazole and their 1- and 5-methyl derivatives with aromatic isocyanates and isothiocyanates, 23 N-arylamides resp. thioamides of benzimidazolyl-2-alpha-cyanoacetic acid were obtained. The structure of the newly compounds (Table 1) was confirmed by NMR and IR spectra. Some of these shown moderate tuberculostatic activity in vitro.
摘要
在2-氰基甲基苯并咪唑及其1-和5-甲基衍生物与芳族异氰酸酯和异硫氰酸酯的反应中，得到了23种苯并咪唑基-2-α-氰基乙酸的N-芳基酰胺和硫代酰胺。通过核磁共振（NMR）和红外光谱（IR）证实了新化合物（表1）的结构。其中一些在体外表现出适度的抗结核活性。
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Reactions of cyanomethylbenzimidazoles. Part III. Reaction of cyanomethylbenzimidazoles with isocyanates and isothiocyanates.氰甲基苯并咪唑的反应。第三部分。氰甲基苯并咪唑与异氰酸酯和异硫氰酸酯的反应。
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