氰甲基苯并咪唑的反应。第四部分。2-[α-氰基-β-芳基-（二烷基）-乙烯基]-苯并咪唑及苯并咪唑基-2-α-氰基乙酸的N-芳基硫代酰胺衍生物及其抗结核活性
Reactions of cyanomethylbenzimidazoles. Part IV. Derivatives of 2-[alpha-cyano-beta-aryl-(dialkyl)-vinyl]-benzimidazole and N-arylthioamides of benzimidazolyl-2-alpha-cyanoacetic acid and their tuberculostatic activity.
作者信息
Milczarska B, Wrześniowska K, Janowiec M
出版信息
Pol J Pharmacol Pharm. 1981 Mar-Apr;33(2):217-21.
PMID:7312722
Abstract
Several derivatives of N-arylthioamide of benzimidazolyl-2-alpha-cyanoacetic acid and 2-(alpha-cyano-beta-chlorophenyl)-benzimidazole and its 4(7)- and 5(6)-methyl derivatives have been obtained. Tuberculostatic activity of these compounds was determined on the Mycobacterium tuberculosis H37Rv strain. LD50 values were determined for derivatives of 2-(alpha-cyano-beta-arylvinyl)-benzimidazoles. The compounds show moderate toxicity.
摘要
已获得苯并咪唑基-2-α-氰基乙酸的N-芳基硫代酰胺以及2-(α-氰基-β-氯苯基)-苯并咪唑及其4(7)-和5(6)-甲基衍生物的几种衍生物。在结核分枝杆菌H37Rv菌株上测定了这些化合物的抑菌活性。测定了2-(α-氰基-β-芳基乙烯基)-苯并咪唑衍生物的半数致死量（LD50）值。这些化合物显示出中等毒性。
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