Shiga K, Sugihara H, Inoue T, Fujita N, Ogawa F, Nakagawa T, Otsuki K, Umamoto I, Taniguchi Y, Nakagawa M
Department of Radiology, Kyoto First Red Cross Hospital.
Kaku Igaku. 1993 Nov;30(11):1359-67.
123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy was performed in twelve normal human subjects, and the distribution and clearance of MIBG were estimated. In PLANAR studies, heart to mediastinum (H/M) and lung to mediastinum activity ratio (L/M) were 2.68 +/- 0.45 and 1.82 +/- 0.23 in initial images, and 2.75 +/- 0.44 and 1.55 +/- 0.13 in delayed images. The clearance of MIBG in the lung was more rapid than that in the heart, 41.6 +/- 4.1 vs. 29.8 +/- 3.2 (%), therefore MIBG cardiac profiles were more clarified in delayed images. In SPECT studies, the regional relative uptake (RRU) in anterior, septal, inferior and lateral wall were 100.0 +/- 0, 93.9 +/- 6.9, 85.0 +/- 10.0 and 104.9 +/- 8.3 (%) in initial images, and 100.0 +/- 0, 96.8 +/- 9.6, 79.4 +/- 8.3 and 99.1 +/- 7.9 (%) in delayed images, respectively. The RRU in inferior wall was significantly lower than those in the other walls. The regional clearance rate (RCR) in these four walls were 25.1 +/- 4.6, 22.5 +/- 8.2, 29.7 +/- 8.3, 29.3 +/- 3.4 (%), respectively. The RCR in inferior and lateral wall were significantly larger than those in anterior and septal walls. The RRU in basal, mid and apical portion were 100.0 +/- 0, 104.5 +/- 3.3, 98.9 +/- 12.1 (%) in initial images, and 100.0 +/- 0, 103.9 +/- 4.5, 96.8 +/- 15.2 (%) in delayed images, respectively. The RRU in mid portion was significantly higher than that in basal portion.(ABSTRACT TRUNCATED AT 250 WORDS)
对12名正常受试者进行了123I-间碘苄胍（MIBG）心肌闪烁显像，并评估了MIBG的分布和清除情况。在平面显像研究中，初始图像中心脏与纵隔（H/M）及肺与纵隔的放射性活度比（L/M）分别为2.68±0.45和1.82±0.23，延迟图像中分别为2.75±0.44和1.55±0.13。MIBG在肺内的清除比在心脏内更快，分别为41.6±4.1%和29.8±3.2%，因此在延迟图像中MIBG的心脏影像更清晰。在单光子发射计算机断层显像（SPECT）研究中，初始图像中前壁、间隔、下壁和侧壁的局部相对摄取率（RRU）分别为100.0±0、93.9±6.9、85.0±10.0和104.9±8.3%，延迟图像中分别为100.0±0、96.8±9.6、79.4±8.3和99.1±7.9%。下壁的RRU显著低于其他壁。这四个壁的局部清除率（RCR）分别为25.1±4.6、22.5±8.2、29.7±8.3、29.3±3.4%。下壁和侧壁的RCR显著高于前壁和间隔壁。基底、中间和心尖部的RRU在初始图像中分别为100.0±0、104.5±3.3、98.9±12.1%，延迟图像中分别为100.0±0、103.9±4.5、96.8±15.2%。中间部的RRU显著高于基底部。（摘要截短于250字）
