Takeuchi T, Ido A, Kashiwagi Y, Ohi S, Hasebe N, Yamashita H, Kikuchi K, Sato J, Ishikawa Y
First Department of Internal Medicine, Asahikawa Medical College.
Kaku Igaku. 1995 Jul;32(7):675-81.
We estimated the systemic and left ventricular (LV) regional myocardial distribution of 123I-BMIPP (beta-methyl-p-iodophenyl-pentadecanoic-acid) in normal subjects (n = 13, mean age 43.9). In planar studies, the count ratios of heart, lung and liver to mediastinum were 2.63, 1.28 and 3.80 in the early images, and 2.23, 1.20 and 2.26 in the delayed images, respectively. The uptake in liver was almost identical with that in heart in the delayed images. In SPECT studies, the regional relative counts in anterior, septal, posterior and lateral LV walls were 100, 98, 96 and 108 (%) in the initial images, and 100, 98, 99 and 107 (%) in the delayed images, respectively. The regional relative uptake was significantly higher in the lateral wall than those in the other parts of LV walls in both images. The relative counts in the basal, mid- and apical portions were 100, 111 and 87 (%) in the initial images, and 100, 113, 92 (%) in the delayed images, respectively. These results suggest that the myocardial regional distribution of BMIPP is not always uniform even in normal subjects. Thus, it is necessary to interpret with caution in the light of these findings, especially for detect in a myocardial lesion in an early phase of cardiomyopathy or a mild myocardial ischemia.
我们评估了123I-BMIPP（β-甲基-对-碘苯基-十五烷酸）在正常受试者（n = 13，平均年龄43.9岁）体内的全身及左心室（LV）局部心肌分布情况。在平面显像研究中，早期图像中心脏、肺和肝脏与纵隔的计数比分别为2.63、1.28和3.80，延迟图像中分别为2.23、1.20和2.26。延迟图像中肝脏的摄取量与心脏几乎相同。在单光子发射计算机断层显像（SPECT）研究中，左心室前壁、间隔壁、后壁和侧壁的局部相对计数在初始图像中分别为100%、98%、96%和108%，延迟图像中分别为100%、98%、99%和107%。在这两种图像中，侧壁的局部相对摄取均显著高于左心室壁的其他部分。基底、中间和心尖部分的相对计数在初始图像中分别为100%、111%和87%，延迟图像中分别为100%、113%、92%。这些结果表明，即使在正常受试者中，BMIPP的心肌局部分布也并非总是均匀的。因此，鉴于这些发现，尤其是在心肌病早期或轻度心肌缺血时检测心肌病变时，有必要谨慎解读。
