Doi Y, Suzuki K, Tanaka M, Fujieda K, Ito T, Hisada T, Morinari H, Harasawa M
Department of Respiratory Medicine, Tokyo Teishine Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Nov;31(11):1385-9.
Bone mineral density (BMD) of the lumbar spine (L2-L4) was measured using dual-energy X-ray absorptiometry (DEXA), and its relationship to total dose of prednisolone and duration of prednisolone therapy was studied in 57 patients with bronchial asthma. There was a significant negative correlation between BMD and total dose of prednisolone (r = -0.463, p < 0.001) and between BMD and duration of prednisolone treatment (r = -0.30, p < 0.05). The half-yearly percent decrease of BMD measured in 17 asthmatic patients was 0.83% (p < 0.01) after correction for age-associated decline. These findings suggest that the reduction of BMD was related to the total dose of prednisolone and the duration of therapy in asthmatics.
采用双能X线吸收法（DEXA）测量57例支气管哮喘患者腰椎（L2-L4）的骨密度（BMD），并研究其与泼尼松龙总剂量及治疗持续时间的关系。BMD与泼尼松龙总剂量之间存在显著负相关（r = -0.463，p < 0.001），BMD与泼尼松龙治疗持续时间之间也存在显著负相关（r = -0.30，p < 0.05）。校正年龄相关下降后，17例哮喘患者半年内BMD的下降百分比为0.83%（p < 0.01）。这些发现表明，哮喘患者BMD的降低与泼尼松龙的总剂量和治疗持续时间有关。
