Konaka C, Kato H, Sato M, Hiyoshi T, Saito H
Department of Surgery, Tokyo Medical College, Japan.
Kyobu Geka. 1994 Jan;47(1):45-8.
From 1950 to 1991, 1,221 lung cancer cases were treated with surgery in Tokyo Medical College Hospital. The 5-year survival rate was achieved in 70.1% for stage I, 49.5% for stage II, 17.0% for stage III A, 0% for stage III B and 8.3% for stage IV respectively. Considering for the survival rate with pN factor in 753 resected cases, the 5-year survival rate of N0, N1, N2 and N3 cases was 65.8%, 38.1%, 16.3% and 0% respectively. In these pN2 group, the 5-year survival rate of single mediastinal lymph node metastasis cases was 35.5%, while that of multiple mediastinal lymph node metastasized cases was 6.9%. The relationship between lymph node metastasis and DNA ploidy pattern was also discussed. The most of N0 cases showed diploid pattern, while N2 cases indicated aneuploid pattern. A mediastinal lymph node dissection of pN2 lung cancer cases may be effective to improve the prognosis of a kind of cases showing biologically low malignant lung cancer.
1950年至1991年期间，东京医科大学医院对1221例肺癌患者进行了手术治疗。I期患者的5年生存率为70.1%，II期为49.5%，IIIA期为17.0%，IIIB期为0%，IV期为8.3%。在753例接受切除手术的病例中，考虑pN因素的生存率，N0、N1、N2和N3病例的5年生存率分别为65.8%、38.1%、16.3%和0%。在这些pN2组中，单发性纵隔淋巴结转移病例的5年生存率为35.5%，而多发性纵隔淋巴结转移病例的5年生存率为6.9%。还讨论了淋巴结转移与DNA倍体模式之间的关系。大多数N0病例表现为二倍体模式，而N2病例则显示非整倍体模式。对pN2肺癌病例进行纵隔淋巴结清扫术可能有效地改善一类生物学上恶性程度较低的肺癌病例的预后。
