Keyak J H, Fourkas M G, Meagher J M, Skinner H B
Rehabilitation Research & Development Service, Department of Veterans Affairs Medical Center, San Francisco, CA.
J Biomed Eng. 1993 Nov;15(6):505-9. doi: 10.1016/0141-5425(93)90066-8.
This study validated an automated method of finite element modelling of bone from CT scan data. After a fresh-frozen cadaveric femur was modelled, strain gauges were attached to the bone at 11 locations and the femur was mechanically tested by applying a load to the femoral head. Linear regression analysis was used to correlate the strains predicted by the model with the experimentally measured strains. The regression results were significant (P < 0.001), indicating that the strain calculated by the FE model is a valid predictor of the measured strain. Verification of the surface strains also supports the validity of the strains and stresses predicted inside the bone. The present study provides a strong rationale for use of this modelling method as a research tool and in possible clinical applications.
本研究验证了一种基于CT扫描数据的骨骼有限元建模自动化方法。对一具新鲜冷冻的尸体股骨进行建模后，在11个位置将应变片附着于骨骼上，并通过对股骨头施加负荷对股骨进行力学测试。采用线性回归分析将模型预测的应变与实验测量的应变进行关联。回归结果具有显著性（P < 0.001），表明有限元模型计算出的应变是测量应变的有效预测指标。表面应变的验证也支持了骨骼内部预测的应变和应力的有效性。本研究为将这种建模方法用作研究工具及可能的临床应用提供了有力的理论依据。
