Fabrication of microscalpels by electrolysis of tungsten wire in a meniscus.

A simple technique has been devised for generating consistent microscalpel blades from tungsten wire for use in microdissections. Electrolysis of the tungsten wire held horizontally in contact with the extended, up-lifted meniscus of an aqueous solution of 1.0 N NaOH sculps the metal into a blade configuration with a very sharp cutting edge. These microscalpels are suitable for dissection of embryonic neural tissues.