Rapp D L, Robbins T W
Psychopharmacology (Berl). 1976 Dec 21;51(1):91-100. doi: 10.1007/BF00426328.
The effects of d-amphetamine on temporal discrimination in the rat were studied. Rats were trained on a two-manipulandum task involving the discrimination between two tones differing only in duration. d-Amphetamine (0.1 - 1.6 mg/kg) disrupted performance on this task, although not in an obvious dose-related manner. Lever biases were enhanced by the drug, but inconsistenly among rats. Enhanced lever bias did not necessarily correlate with deterioration of performance. The drug lengthened both response latency and the performance of terminal components of the operant chain. However the characteristic pattern of response latencies produced by the two tones was not altered significantly by the drug. The results are discussed in terms of whether the drug disrupts discrimination performance by a direct effect on processes of temporal discrimination or indirectly, by its other effects on behavior.
研究了右旋苯丙胺对大鼠时间辨别能力的影响。大鼠接受了一项双操作任务训练，该任务涉及区分仅持续时间不同的两种音调。右旋苯丙胺（0.1 - 1.6毫克/千克）干扰了这项任务的表现，尽管不是以明显的剂量相关方式。药物增强了杠杆偏好，但在大鼠中并不一致。增强的杠杆偏好不一定与表现恶化相关。药物延长了反应潜伏期和操作链终端成分的表现。然而，两种音调产生的反应潜伏期的特征模式并未因药物而显著改变。根据药物是直接影响时间辨别过程还是通过对行为的其他影响间接干扰辨别表现来讨论结果。
