Schechter M D, Boja J W
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Pharmacol Biochem Behav. 1988 Aug;30(4):1085-8. doi: 10.1016/0091-3057(88)90144-x.
Rats were trained to discriminate between the stimulus properties of intraperitoneally administered d-amphetamine (0.8 mg/kg) and its vehicle in a two-lever, food-motivated operant task. Once trained, doses of the norepinephrine reuptake inhibiting agent nisoxetine, ranging from 10 to 20 mg/kg, were administered to investigate if the amphetamine-trained rats would generalize to this agent. This did not, however, occur. Thus, it would seem that noradrenergic mechanisms have a negligible role in the production of the amphetamine-induced discriminative stimulus cue in the rat. Previous evidence that indicated a noradrenergic mediation of amphetamine discrimination in the mouse contrasted with the present results in rats and this discrepancy should warrant caution in comparing results of discriminative studies in these two species.
在一项双杠杆、以食物为动机的操作性任务中，训练大鼠区分腹腔注射d-苯丙胺（0.8毫克/千克）及其溶剂的刺激特性。训练完成后，给予剂量范围为10至20毫克/千克的去甲肾上腺素再摄取抑制剂尼索西汀，以研究经苯丙胺训练的大鼠是否会对该药物产生泛化反应。然而，这种情况并未发生。因此，去甲肾上腺素能机制在大鼠苯丙胺诱导的辨别性刺激线索产生中似乎作用甚微。先前有证据表明去甲肾上腺素能介导小鼠对苯丙胺的辨别，这与目前大鼠的结果形成对比，这种差异在比较这两个物种的辨别性研究结果时应谨慎对待。
