• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study.

作者信息

Serretta V, Corselli G, Piazza B, Lio D, Gervasi F, Salerno S, Pavone-Macaluso M

机构信息

Department of Urology, Civic Hospital, Palermo, Italy.

出版信息

Urol Res. 1993;21(5):353-7. doi: 10.1007/BF00296836.

DOI:10.1007/BF00296836
PMID:8279093
Abstract

A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesical instillations of epirubicin and interferon-alpha-2b and to evaluate which sequence could enhance the release of cytokines in the urine. Our investigations showed a significant increase in urinary concentrations of interleukins in patients who received the sequential intravesical administration of epirubicin and interferon-alpha-2b. Higher urinary concentrations of interleukins and a lower recurrence rate were detected in patients who received interferon-alpha-2b 24h after epirubicin instillation.

摘要

相似文献

1
Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study.
Urol Res. 1993;21(5):353-7. doi: 10.1007/BF00296836.
2
A pilot study comparing different dose levels and administration schedules of interferon-alpha 2b combined with epirubicin for prevention of recurrence in bladder cancer.一项比较干扰素α-2b与表柔比星不同剂量水平及给药方案预防膀胱癌复发的前瞻性研究。
Anticancer Drugs. 1992 May;3 Suppl 1:19-23. doi: 10.1097/00001813-199205000-00005.
3
A controlled study of intravesical epirubicin with or without alpha 2b-interferon as prophylaxis for recurrent superficial transitional cell carcinoma of the bladder. Finnish Multicentre Study Group.
Br J Urol. 1995 Dec;76(6):697-701. doi: 10.1111/j.1464-410x.1995.tb00759.x.
4
Intravesical sequential combination of epirubicin and interferon alpha-2b in patients affected by superficial transitional cell carcinoma of the bladder. Results of a pilot study at Palermo University and proposal of a basic research.表柔比星与干扰素α-2b膀胱内序贯联合治疗浅表性膀胱移行细胞癌患者。巴勒莫大学一项初步研究的结果及基础研究建议。
Prog Clin Biol Res. 1991;370:185-93.
5
Chemoimmunotherapy for prophylaxis of recurrence in superficial bladder cancer: interferon-alpha 2b versus interferon-alpha 2b with epirubicin.化疗免疫疗法预防浅表性膀胱癌复发：α-干扰素2b与α-干扰素2b联合表柔比星的比较
Anticancer Drugs. 1992 May;3 Suppl 1:25-7. doi: 10.1097/00001813-199205000-00006.
6
Intravesical Bacillus Calmette-Guérin Versus Combination of Epirubicin and Interferon-α2a in Reducing Recurrence of Non-Muscle-invasive Bladder Carcinoma: FinnBladder-6 Study.膀胱内卡介苗与表柔比星和α2a 干扰素联合应用降低非肌肉浸润性膀胱癌复发：FinnBladder-6 研究。
Eur Urol. 2016 Aug;70(2):341-7. doi: 10.1016/j.eururo.2016.03.034. Epub 2016 Apr 13.
7
Efficacy of escalating doses of intravesical interferon alpha-2b in reducing recurrence rate and progression in superficial transitional cell carcinoma.膀胱内递增剂量α-2b干扰素在降低浅表性移行细胞癌复发率及进展方面的疗效
Br J Urol. 1998 Dec;82(6):829-34. doi: 10.1046/j.1464-410x.1998.00890.x.
8
[Intravesical instillation with epirubicin as a prophylactic treatment for superficial bladder cancer--using two different schedules].[表柔比星膀胱内灌注作为浅表性膀胱癌的预防性治疗——采用两种不同方案]
Hinyokika Kiyo. 2008 Nov;54(11):711-6.
9
Transurethral resection with perioperative instilation on interferon-alpha or epirubicin for the prophylaxis of recurrent primary superficial bladder cancer: a prospective randomized multicenter study--Finnbladder III.
J Urol. 1999 Apr;161(4):1133-5; discussion 1135-6. doi: 10.1016/s0022-5347(01)61609-4.
10
Prevention of recurrence with epirubicin and lactobacillus casei after transurethral resection of bladder cancer.表柔比星联合干酪乳杆菌预防膀胱癌经尿道切除术后复发
J Urol. 2008 Feb;179(2):485-90. doi: 10.1016/j.juro.2007.09.031.

本文引用的文献

1
Current status of intravesical chemotherapy trials in the EORTC Urological Group. An overview.
Cancer Chemother Pharmacol. 1987;20 Suppl:S67-71. doi: 10.1007/BF00262490.
2
Absorption of anticancer drugs through bladder epithelium.
Urology. 1986 Feb;27(2):148-57. doi: 10.1016/0090-4295(86)90372-9.
3
Intraluminal interleukin 2 and bacillus Calmette-Guerin for treatment of bladder cancer: a preliminary report.腔内注射白细胞介素2和卡介苗治疗膀胱癌：初步报告。
J Urol. 1987 Feb;137(2):216-9. doi: 10.1016/s0022-5347(17)43958-9.
4
Detection of interleukin 2 in the urine of patients with superficial bladder tumors after treatment with intravesical BCG.膀胱内灌注卡介苗治疗后浅表性膀胱肿瘤患者尿液中白细胞介素2的检测
J Urol. 1986 Oct;136(4):970-4. doi: 10.1016/s0022-5347(17)45142-1.
5
Alpha-interferon in superficial bladder cancer: a Northern California Oncology Group Study.α干扰素治疗浅表性膀胱癌：北加利福尼亚肿瘤学组的研究
J Clin Oncol. 1988 Mar;6(3):476-83. doi: 10.1200/JCO.1988.6.3.476.
6
Helper strategy in tumor immunology: expansion of helper lymphocytes and utilization of helper lymphokines for experimental and clinical immunotherapy.肿瘤免疫学中的辅助策略：辅助淋巴细胞的扩增及辅助淋巴因子在实验性和临床免疫治疗中的应用
Cancer Metastasis Rev. 1988 Dec;7(4):289-309. doi: 10.1007/BF00051371.
7
Tumor immunotherapy by local injection of interleukin 2 and non-reactive lymphocytes. Experimental and clinical results.通过局部注射白细胞介素2和无反应性淋巴细胞进行肿瘤免疫治疗。实验和临床结果。
Prog Exp Tumor Res. 1988;32:187-212. doi: 10.1159/000414679.
8
Murine interleukin-4 displays potent anti-tumor activity in vivo.小鼠白细胞介素-4在体内显示出强大的抗肿瘤活性。
Cell. 1989 May 5;57(3):503-12. doi: 10.1016/0092-8674(89)90925-2.
9
Intravesical interferon treatment of superficial bladder cancer.表浅膀胱癌的膀胱内干扰素治疗
Urology. 1989 Oct;34(4 Suppl):84-6; discussion 87-96. doi: 10.1016/0090-4295(89)90240-9.
10
Immunohistochemical detection of tissue-infiltrating lymphocytes in bladder tumors.膀胱肿瘤中组织浸润淋巴细胞的免疫组化检测
Urol Int. 1989;44(1):5-9. doi: 10.1159/000281440.