Schlemmer A, Hassager C, Risteli J, Risteli L, Jensen S B, Christiansen C
Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
Acta Endocrinol (Copenh). 1993 Nov;129(5):388-92. doi: 10.1530/acta.0.1290388.
In order to determine whether bone turnover varies during the normal menstrual cycle, we measured biochemical markers of bone resorption (serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (sICTP), fasting urinary hydroxyproline/creatinine, fasting urinary pyridinoline/creatinine and fasting urinary deoxypyridinoline/creatinine) and bone formation (plasma osteocalcin, serum carboxy-terminal propeptide of type I procollagen and serum alkaline phosphatase) in ten healthy premenopausal women every two or three days for a complete menstrual cycle. A cyclic pattern was detected in sICTP, with its nadir during the follicular phase and its peak during the luteal phase, and an overall variation of 17% during the menstrual cycle (p = 0.004). No cyclic changes were observed in the urinary parameters of bone resorption or in the biochemical markers of bone formation. We conclude that sICTP, a new biochemical marker of bone resorption, undergoes small variations during a normal menstrual cycle in premenopausal women, whereas the biochemical markers of bone formation remain constant.
为了确定在正常月经周期中骨转换是否变化,我们在一个完整的月经周期内,每两到三天对10名健康的绝经前女性测量骨吸收(血清I型胶原吡啶啉交联羧基末端肽(sICTP)、空腹尿羟脯氨酸/肌酐、空腹尿吡啶啉/肌酐和空腹尿脱氧吡啶啉/肌酐)和骨形成(血浆骨钙素、血清I型前胶原羧基末端前肽和血清碱性磷酸酶)的生化标志物。在sICTP中检测到一种周期性模式,其在卵泡期最低,在黄体期最高,在月经周期中总体变化为17%(p = 0.004)。在骨吸收的尿液参数或骨形成的生化标志物中未观察到周期性变化。我们得出结论,sICTP作为一种新的骨吸收生化标志物,在绝经前女性的正常月经周期中会发生微小变化,而骨形成的生化标志物保持不变。