Hunter J B, Lonsdale R J, Wenham P W, Frostick S P
Department of Orthopaedic and Accident Surgery, Queen's Medical Centre, Nottingham.
BMJ. 1993 Jul 3;307(6895):53-5. doi: 10.1136/bmj.307.6895.53.
Heparin induced thrombocytopenia with thrombosis, or the "white clot syndrome," is a rare but recognised complication of heparin therapy. The syndrome is idiosyncratic, immune mediated, and not dose dependent and therefore is equally likely to occur with prophylactic and therapeutic heparin dosage regimens. Despite published reports on the subject we were alarmed that many surgeons who regularly use heparin to prevent or treat thrombosis were unaware that heparin can induce thrombotic complications in susceptible patients. We present three typical case histories, a brief discussion of the condition, and some guidelines on its prevention and treatment.
肝素诱导的血小板减少伴血栓形成，即“白血栓综合征”，是肝素治疗一种罕见但已被认识的并发症。该综合征是特异质性、免疫介导的，且与剂量无关，因此在预防性和治疗性肝素给药方案中发生的可能性相同。尽管有关于该主题的已发表报告，但我们感到震惊的是，许多经常使用肝素预防或治疗血栓形成的外科医生并未意识到肝素可在易感患者中诱发血栓形成并发症。我们展示三个典型病例史，对该病症进行简要讨论，并给出一些关于其预防和治疗的指导原则。
