Senati E, Barioglio A, Petrucci V
USL 13-Ascoli Piceno-Ospedale G.C. Mazzoni, Divisione di Chirurgia Generale I.
Minerva Cardioangiol. 1995 Jul-Aug;43(7-8):335-8.
Heparin induced thrombocytopenia with thrombosis, or the "white clot syndrome" is a rare but very important complication of heparin therapy. The syndrome is idiosyncrasic, immune-mediated and not dose dependent and therefore is equally likely to occur with prophylactic and therapeutic heparin dosage regimens. We report a typical case of HIT that occurs with prophylactic heparin therapy and results in bilateral amputation of the lower limbs. We discuss this important condition and some guidelines on its prevention and treatment.
肝素诱导的血小板减少伴血栓形成，即“白色血栓综合征”，是肝素治疗中一种罕见但非常重要的并发症。该综合征是特发性的、免疫介导的，且与剂量无关，因此在预防性和治疗性肝素给药方案中发生的可能性相同。我们报告一例典型的预防性肝素治疗引发的肝素诱导的血小板减少伴血栓形成病例，该病例导致双下肢截肢。我们讨论了这一重要病症及其预防和治疗的一些指导原则。
