Horstman J K, Ahmadu-Suka F, Norrdin R W
Orthopaedic Research Center of the Rockies, Fort Collins, Colorado 80525.
Arthroscopy. 1993;9(5):509-18. doi: 10.1016/s0749-8063(05)80397-4.
Biopsy samples were obtained arthroscopically from 21 patients who had undergone anterior cruciate ligament (ACL) reconstruction using rolled, freeze-dried fascia lata allograft in order to evaluate progressive histologic changes toward maturation. The study period was 3-20 months postoperation. The mean age (+/- SEM) was 31.9 +/- 10.3. Histomorphometry was used for quantitative evaluation. Arthroscopic examination showed fully synovialized allografts in all patients. Varying degrees of degenerative tissues were observed histologically. There was a significant, direct correlation between the percentage of polarized tissue and the maturity of the biopsy specimen (r = 0.9; p < 0.04). The mean area of polarization in the postrehabilitation period (10-20 months) was significantly higher (p < 0.01) than in the rehabilitation period (3-20 months). Overall, there was a progressive decrease in cellularity and vascularity as the allograft matured. Compared with the biopsy samples of normal ACLs, the allograft was still undergoing maturation 20 months postoperatively.
通过关节镜从21例使用卷起的冻干阔筋膜异体移植物进行前交叉韧带（ACL）重建的患者身上获取活检样本，以评估其向成熟发展的组织学变化。研究期为术后3至20个月。平均年龄（±标准误）为31.9±10.3。采用组织形态计量学进行定量评估。关节镜检查显示所有患者的异体移植物均已完全滑膜化。组织学观察到不同程度的退变组织。极化组织的百分比与活检标本的成熟度之间存在显著的直接相关性（r = 0.9；p < 0.04）。康复后期（10 - 20个月）的平均极化面积显著高于康复期（3 - 10个月）（p < 0.01）。总体而言，随着异体移植物成熟，细胞数量和血管数量逐渐减少。与正常ACL的活检样本相比，异体移植物在术后20个月仍在成熟。
