Treit D, Pesold C, Rotzinger S
Department of Psychology, University of Alberta, Edmonton, Canada.
Behav Neurosci. 1993 Oct;107(5):770-85. doi: 10.1037//0735-7044.107.5.770.
Effects of septal and amygdaloid lesions were compared in 2 models of rat "anxiety." Septal lesions decreased burying behavior in the "shock-probe burying test" and increased open-arm exploration in the "elevated plus-maze test," whereas amygdaloid lesions produced neither of these anxiolytic effects. However, amygdaloid lesions increased rats' contacts of the electrified probe, an anxiolytic effect not produced by septal lesions. Each of these distinct, anxiolytic effects of septal or amygdaloid lesions were displayed together in animals with lesions of both structures. Furthermore, the magnitude of these anxiolytic effects after combined lesions was comparable to their magnitude after individual lesions. Taken together, these results suggest the amygdala and the septum independently control the expression of different fear-related behaviors.
在两种大鼠“焦虑”模型中比较了隔区和杏仁核损伤的影响。隔区损伤在“电击探针掩埋试验”中减少了掩埋行为，在“高架十字迷宫试验”中增加了对开放臂的探索，而杏仁核损伤则未产生这些抗焦虑作用。然而，杏仁核损伤增加了大鼠与带电探针的接触，这是隔区损伤未产生的抗焦虑作用。隔区或杏仁核损伤的这些独特的抗焦虑作用在两个结构均有损伤的动物中同时出现。此外，联合损伤后这些抗焦虑作用的程度与单个损伤后的程度相当。综上所述，这些结果表明杏仁核和隔区独立控制不同恐惧相关行为的表达。
