Dohanich G P, Ross S M, Francis T J, Fader A J, Wee B E, Brazier M M, Menard C S
Department of Psychology, Tulane University, New Orleans, Louisiana 70118.
Behav Neurosci. 1993 Oct;107(5):819-26. doi: 10.1037//0735-7044.107.5.819.
The effects of the muscarinic antagonist scopolamine on lordosis, solicitation, pacing, approach, attractivity, and activity were evaluated in ovariectomized rats brought into sexual receptivity with estrogen and progesterone. Systemic (1 mg/rat) or intraventricular (10 micrograms bilaterally) administration of scopolamine significantly reduced the incidence of lordosis and solicitation behaviors and disrupted typical pacing of sexual contacts with a stimulus male. In addition, females avoided contact with a stimulus male, but not a stimulus female, following intraventricular infusion of scopolamine. The levels of general activity and frequencies of sexual contacts were similar in females treated intraventricularly with scopolamine and vehicle solutions. Consequently, scopolamine disrupted various components of sexual behavior, including lordosis, solicitation, pacing, and approach, without altering female attractivity or general activity.
在通过雌激素和孕酮诱导进入性接受状态的去卵巢大鼠中，评估了毒蕈碱拮抗剂东莨菪碱对脊柱前凸、求偶行为、踱步、接近、吸引力和活动的影响。全身性（1毫克/只大鼠）或脑室内（双侧各10微克）给予东莨菪碱显著降低了脊柱前凸和求偶行为的发生率，并扰乱了与刺激雄性的典型性接触踱步。此外，脑室内注入东莨菪碱后，雌性大鼠会避免与刺激雄性接触，但不会避免与刺激雌性接触。脑室内给予东莨菪碱和赋形剂溶液的雌性大鼠的一般活动水平和性接触频率相似。因此，东莨菪碱扰乱了性行为的各个组成部分，包括脊柱前凸、求偶行为、踱步和接近行为，而不会改变雌性的吸引力或一般活动。
