Wee B E, Francis T J, Lee C Y, Lee J M, Dohanich G P
Department of Psychology, Tulane University, New Orleans, LA 70118, USA.
Physiol Behav. 1995 Jul;58(1):97-100. doi: 10.1016/0031-9384(95)00029-i.
The effects of the muscarinic antagonist, scopolamine, on the behavior of female rats in a mate preference test were determined. Ovariectomized rats were primed with sufficient doses of estradiol benzoate (0.25 micrograms for 3 days) and progesterone (500 micrograms) to activate full sexual receptivity. Beginning 15 min after intraperitoneal injection of saline (0.4 ml/kg) or scopolamine hydrochloride (1 mg/kg), females were tested in an arena divided into three compartments. Females treated with scopolamine clearly avoided a compartment occupied by a gonadally intact stimulus male, instead preferring a compartment occupied by a castrated male or an empty neutral compartment. Direct contact with an intact male was a critical feature of this avoidance because females treated with scopolamine did not avoid intact males that were confined within a chamber that prevented physical contact between the male and female. Results indicate that female rats treated with scopolamine avoid direct physical contact with sexually active males, possibly due to an alteration in sexual motivation and/or the aversive nature of this interaction.
研究了毒蕈碱拮抗剂东莨菪碱对雌性大鼠在配偶偏好测试中行为的影响。对去卵巢大鼠用足够剂量的苯甲酸雌二醇（0.25微克，连续3天）和孕酮（500微克）进行预处理，以激活完全的性接受能力。在腹腔注射生理盐水（0.4毫升/千克）或盐酸东莨菪碱（1毫克/千克）15分钟后，将雌性大鼠置于一个分为三个隔室的场地中进行测试。用东莨菪碱处理的雌性大鼠明显避开了由性腺完整的刺激雄性占据的隔室，而是更喜欢由去势雄性占据的隔室或空的中性隔室。与完整雄性的直接接触是这种回避行为的一个关键特征，因为用东莨菪碱处理的雌性大鼠不会避开被限制在一个阻止雌雄之间身体接触的小室内的完整雄性。结果表明，用东莨菪碱处理的雌性大鼠避免与性活跃的雄性直接身体接触，这可能是由于性动机的改变和/或这种相互作用的厌恶性质。
