Desborough J P, Jones P M, Persaud S J, Landon M J, Howell S L
Department of Anaesthesia, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Br J Anaesth. 1993 Dec;71(6):873-6. doi: 10.1093/bja/71.6.873.
We have investigated the effects of isoflurane on insulin secretion in vitro from rat isolated islets of Langerhans and found a significant, dose-related and reversible inhibition of insulin secretion. Isoflurane 2% decreased insulin secretion stimulated by glucose 20 mmol litre-1 to basal, nonstimulated values. In other studies to identify the stage in the stimulus secretion pathway for insulin at which the anaesthetic may exert an inhibitory action, we have stimulated insulin release using glyceraldehyde and a phorbol ester. Insulin secretion induced by these secretagogues was also blocked by isoflurane. This suggests that the inhibitory effect of the anaesthetic agent may be at a site distal to stimulation of insulin secretion by glyceraldehyde and phorbol esters.
我们研究了异氟烷对大鼠离体胰岛胰岛素分泌的体外影响，发现异氟烷对胰岛素分泌有显著的、剂量相关的且可逆的抑制作用。2%的异氟烷可使由20毫摩尔/升葡萄糖刺激引起的胰岛素分泌降至基础的、未受刺激时的值。在其他旨在确定麻醉剂可能发挥抑制作用的胰岛素刺激-分泌途径阶段的研究中，我们使用甘油醛和佛波酯刺激胰岛素释放。这些促分泌剂诱导的胰岛素分泌也被异氟烷阻断。这表明麻醉剂的抑制作用可能发生在甘油醛和佛波酯刺激胰岛素分泌的位点的下游。
