111例葡萄膜黑色素瘤摘除术后的预后因素
Prognostic factors following enucleation of 111 uveal melanomas.
作者信息
Coleman K, Baak J P, Van Diest P, Mullaney J, Farrell M, Fenton M
机构信息
Department of Pathology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
出版信息
Br J Ophthalmol. 1993 Nov;77(11):688-92. doi: 10.1136/bjo.77.11.688.
Abstract
Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival analysis was carried out using Kaplan-Meier curves and the differences between the curves were analysed with the Mantel-Cox test. Multivariate analysis used the Cox proportional hazards model. Univariate analysis isolated each of the following as significant prognosticators: largest tumour diameter (LTD) (p < 0.002), presence of epithelioid cells (p < 0.03), and glaucoma (p < 0.001). A combination of cell type, glaucoma, and LTD (p < 0.0001) had strong and independent prognostic significance in multivariate analysis. The results of this series are compared with previous studies and the value of cell type information and new quantitative parameters is discussed.
摘要
我们收集了1964年至1987年间因葡萄膜黑色素瘤接受眼球摘除术的111例患者的随访信息，术后最短随访期为5年。采用Kaplan-Meier曲线进行单因素生存分析，并用Mantel-Cox检验分析曲线之间的差异。多因素分析采用Cox比例风险模型。单因素分析确定以下各项为显著的预后因素：最大肿瘤直径（LTD）（p < 0.002）、上皮样细胞的存在（p < 0.03）和青光眼（p < 0.001）。在多因素分析中，细胞类型、青光眼和LTD的组合（p < 0.0001）具有强烈且独立的预后意义。将本系列研究结果与先前的研究进行比较，并讨论细胞类型信息和新的定量参数的价值。
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