Watanabe M, Yamada Y, Iguchi K, Minnikin D E
Research Institute of BCG, Tokyo, Japan.
Biochim Biophys Acta. 1994 Jan 3;1210(2):174-80. doi: 10.1016/0005-2760(94)90118-x.
From one clinical isolate of Mycobacterium tuberculosis, two new phenolic glycolipids(PGLs) were obtained as its major PGLs. These were dimycocerosyl esters of 2,4-di-O-methyl-fucopyranosyl-(alpha 1-->3)-rhamnopyranosyl-(alpha 1-->3)-2-O-methyl-rhamnopyranosyl-(alpha 1-->)-phenolphthiocerol A and -phenolphthiotriol A, which were produced by this strain at a ratio of about 5:1. Another clinical isolate of this species was found to produce PGL-tb1 and its analogue, 2,3,4-tri-O-methyl-fucopyranosyl-(alpha 1-->3)-rhamnopyranosyl-(alpha 1-->3)-2-O-methyl-rhamnopyranosyl-(alpha 1-->)-phenolphthiotriol A at a ratio of about 1:3. The fact that different strains of M. tuberculosis produce chemically different PGLs as their major PGLs may be related to the diversity of virulence of the clinical isolates of M. tuberculosis.
从一株结核分枝杆菌临床分离株中，获得了两种新的酚糖脂（PGLs）作为其主要的PGLs。它们是2,4-二-O-甲基-岩藻吡喃糖基-（α1→3）-鼠李吡喃糖基-（α1→3）-2-O-甲基-鼠李吡喃糖基-（α1→）-酚硫醇A和-酚硫三醇A的二霉菌酸酯，该菌株以约5:1的比例产生这些物质。发现该物种的另一株临床分离株以约1:3的比例产生PGL-tb1及其类似物2,3,4-三-O-甲基-岩藻吡喃糖基-（α1→3）-鼠李吡喃糖基-（α1→3）-2-O-甲基-鼠李吡喃糖基-（α1→）-酚硫三醇A。结核分枝杆菌不同菌株产生化学性质不同的PGLs作为其主要PGLs这一事实，可能与结核分枝杆菌临床分离株毒力的多样性有关。
