Jain M R, Patil P P, Subhedar N
Department of Pharmaceutical Sciences, Nagpur University, India.
Neuroreport. 1993 Oct 25;5(1):69-71. doi: 10.1097/00001756-199310000-00017.
While the inhibitory effect of metyrapone on the biosynthesis of adrenal corticosteroid hormones is well known, the drug has not been tested for central actions. The present study is aimed at finding out the direct central action of metyrapone, if any, employing feeding behaviour as a test parameter. Low doses of metyrapone (10-1000 ng) administered via an i.c.v. route reduced the food intake in a dose dependent manner; the effect was functionally antagonized by concomitant administration of anti-CRF antisera. The results reveal for the first time, that metyrapone might be capable of exerting a direct action on the adrenal cortex.
虽然甲吡酮对肾上腺皮质类固醇激素生物合成的抑制作用是众所周知的，但该药物尚未进行中枢作用的测试。本研究旨在通过将摄食行为作为测试参数，来探究甲吡酮是否存在直接的中枢作用。通过脑室内途径给予低剂量的甲吡酮（10 - 1000纳克）可使食物摄入量呈剂量依赖性减少；同时给予抗促肾上腺皮质激素释放因子抗血清可在功能上拮抗该作用。结果首次表明，甲吡酮可能对肾上腺皮质具有直接作用。
