Mitchell H M, Bohane T, Hawkes R A, Lee A
School of Microbiology and Immunology, University of New South Wales, Sydney, Australia.
Zentralbl Bakteriol. 1993 Sep;280(1-2):128-36. doi: 10.1016/s0934-8840(11)80948-5.
Although H. pylori is now well established as the aetiological agent of acute or chronic gastritis and a predisposing factor in peptic ulceration knowledge regarding the transmission of this organism is unclear. The aim of this study was to examine the prevalence of H. pylori infection in the family members of index children infected with this organism and to examine the role of ethnic background and the relationship of hepatitis A infection to H. pylori infection. The H. pylori status of three groups of subjects, the family members of 21 children shown by endoscopical and histological examination to be infected with H. pylori, the family members of 17 children who had been the index case in a hepatitis study and a control group of Australian blood donors and children were examined using an IgG ELISA. The results of this study showed an increased prevalence of H. pylori infection to exist in the family members of index children infected with H. pylori compared with the family members of children not infected with H. pylori and an age matched blood donor control group. This increased prevalence of H. pylori infection was not dependent on ethnic background and appeared to be unrelated to the hepatitis A status of subjects. These results strongly support the view that transmission of H. pylori is person to person and that transmission may not be the faecal oral route.
虽然幽门螺杆菌现已被确认为急性或慢性胃炎的病原体以及消化性溃疡的一个诱发因素，但关于这种微生物的传播方式的了解尚不清楚。本研究的目的是检测感染该病原体的索引儿童家庭成员中幽门螺杆菌感染的患病率，并研究种族背景的作用以及甲型肝炎感染与幽门螺杆菌感染的关系。使用IgG酶联免疫吸附测定法检测了三组受试者的幽门螺杆菌感染状况，这三组受试者分别是：经内镜和组织学检查显示感染幽门螺杆菌的21名儿童的家庭成员、在一项肝炎研究中曾作为索引病例的17名儿童的家庭成员以及一组澳大利亚献血者和儿童组成的对照组。本研究结果显示，与未感染幽门螺杆菌的儿童的家庭成员以及年龄匹配的献血者对照组相比，感染幽门螺杆菌的索引儿童的家庭成员中幽门螺杆菌感染的患病率有所增加。幽门螺杆菌感染患病率的增加并不取决于种族背景，而且似乎与受试者的甲型肝炎感染状况无关。这些结果有力地支持了以下观点：幽门螺杆菌是通过人与人之间传播的，而且传播途径可能不是粪口途径。
