Paulsen E, Andersen K E
Department of Dermatology, Odense University Hospital, Denmark.
Contact Dermatitis. 1993 Oct;29(4):195-201. doi: 10.1111/j.1600-0536.1993.tb03537.x.
During our first year of routine testing with Compositae allergens and extracts, contact allergy to Compositae was frequently found in eczema patients (4.5%), especially in middle-aged or elderly persons. Based on clinical patterns, patch test reactions and the long-term course of the disease, 4 groups of patients were recognized: (a) a small group with localized eczema; (b) another with classic Compositae dermatitis of exposed skin; (c) a 3rd group, the largest, with localized eczema that suddenly one summer turned into a widespread dermatitis; (d) a 4th group with a vesicular hand eczema and more-or-less widespread dermatitis with seasonal variation from the beginning. 65% of the patients had vesicular hand eczema at some time, partly reflecting the frequency of atopy (25%) and metal allergy (44%). 75% of the patients had contact allergy to > or = 1 compounds besides Compositae. Thus, Compositae allergy may be primary, e.g., in young patients with occupational plant contact, or secondary to other contact allergies, perhaps as a result of increased individual susceptibility. The clinical patterns in the latter patients were most often a widespread dermatitis with summer exacerbation. The variability in the clinical picture makes routine patch testing with Compositae allergens recommendable.
在我们使用菊科过敏原和提取物进行常规检测的第一年，湿疹患者中经常发现对菊科的接触性过敏（4.5%），尤其是在中年或老年人中。根据临床症状、斑贴试验反应和疾病的长期病程，识别出4组患者：（a）一小部分患有局限性湿疹的患者；（b）另一部分是暴露皮肤出现典型菊科皮炎的患者；（c）第三组也是人数最多的一组，患有局限性湿疹，在某个夏天突然发展为广泛性皮炎；（d）第四组患者从一开始就患有水疱性手部湿疹和或多或少广泛的皮炎，并伴有季节性变化。65%的患者在某些时候患有水疱性手部湿疹，部分反映了特应性（25%）和金属过敏（44%）的发生率。75%的患者除了对菊科过敏外，还对≥1种化合物有接触性过敏。因此，菊科过敏可能是原发性的，例如在职业性接触植物的年轻患者中，或者是继发于其他接触性过敏，可能是由于个体易感性增加。后一组患者的临床症状最常见的是广泛性皮炎，夏季加重。临床表现的变异性使得对菊科过敏原进行常规斑贴试验是可取的。
